The new aparthotel will be located next to the proposed AC by Marriott hotel, which is already under construction.
The site, currently used for parking, is bounded by Mason Street, Cable Street, Cross Keys Street and Adlington Street in New Cross.
The aparthotel will be a nine-storey building with 224 apartments. There will be a reception, a café, an exercise room and a laundry area on the ground floor with the bedrooms on the upper floors.
The aparthotel will be operated by Staycity.
It will be Staycity’s fourth aparthotel in Manchester.
The group has one at Gateway House on the Piccadilly station approach road and a second in Laystall Street in Ancoats. A third is planned in St Peter’s Square.
